China's first adult single cord blood stem cell transplantation for blood cancer success

Release date: 2017-05-23

On May 8, Zhang, a 35-year-old leukemia patient, left the hospital after undergoing cord blood stem cell transplantation in the First Hospital of Jida, preparing to start a new life. Her discharge marked the success of the first adult cord blood transplant in Jilin Province.

According to reports, patient Zhang was diagnosed as acute myeloid leukemia MLL-AF9 positive (medium risk group) in August 2016. After two courses of chemotherapy, the patient's condition was relieved. Professor Gao Sujun, a blood disease expert at the Cancer Center of the First Affiliated Hospital of Jilin University, said that for patients with such high risk of recurrence, the only means of cure is allogeneic hematopoietic stem cell transplantation. However, there is no suitable blood donor in Zhang. There is uncertainty in finding the unrelated donor in the bone marrow bank, and the search period is long. The patient's condition may recur during the waiting process. Therefore, Professor Gao Sujun decided to carry out cord blood hematopoietic stem cell transplantation for patients.



While screening cord blood, the medical team of the First Affiliated Hospital of Jilin University continued to consolidate the treatment for patients, and also invited the top umbilical blood transplantation expert from China and the director of Anhui Provincial Hospital Sun Zimin to give guidance. After multiple screening comparisons, a higher degree of cord blood was found in the Shanghai cord blood bank, and the number of cells met the transplant requirements. In addition, in order to ensure a smooth transplant, the treatment plan selected the "systemic radiotherapy (TBI) + chemotherapy" program that is most conducive to umbilical cord blood stem cell implantation. The medical team met three times to study the details of the transplant. The transplant plan was revised three times by Sun Zimin. Finalize.

On February 11, the transplant officially began. On February 18, 37.5 ml of cord blood enriched in hematopoietic stem cells were injected into the patient; 21 days later, the patient was implanted with granulocytes; after 35 days, the patient successfully walked out of the laminar flow ward; after 38 days, the patient was plated; 70 days later The patient walked out of the hospital door, marking the first successful single-part cord blood transplant in our province.

According to reports, the transplant team led by Prof. Gao Sujun from the First Hospital of Jilin University has completed more than 220 cases of various types of hematopoietic stem cell transplantation since the transplantation work in 2010. Among them, irrelevant donor transplantation and cord blood transplantation have filled the blank of this work in our province. Now, the first hospital of Jida can complete all types of transplants independently, and can achieve better curative effect, especially in the treatment of aplastic anemia by haploid transplantation, which indicates that the hematopoietic stem cell transplantation technology of Jida Hospital has reached the domestic advanced level.

Source: Jilin Daily

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