Release date: 2017-03-30
Nerve cells are not only found in the brain, but also throughout the body. There are more than 100 million various nerve cells in the gastrointestinal tract, which regulate the secretion of gastrointestinal activities and digestive hormones. Previously, although people stressed that nervousness can cause cancer and various diseases, its cause and importance are not well known.
The joint research team of the University of Tokyo and the University of Columbia in the United States used transgenic technology to make the green cells of the mouse digestive tract responsible for secreting the neurotransmitter acetylcholine green, thus successfully observing where acetylcholine came from. The results showed that acetylcholine-secreting nerve cells surround the gastric stem cells, and plexus cells in mucosal cells also produce acetylcholine. In addition, these nerve cells and plexus cells gradually proliferate during the onset of gastric cancer in mice, and a large amount of acetylcholine is produced inside the tissue.
Based on this finding, the researchers suspect that it is this excess of acetylcholine that stimulates cancer cells to release substances that promote nerve growth. The experiment also found that in gastric cancer cells, a hormone called nerve growth factor (NGF) is indeed produced in large quantities by stimulation with acetylcholine.
Furthermore, the researchers made mice with abnormal numbers of nerve cells in the stomach, and found abnormal nerves in the stomach and developed rapidly, and gastric cancer naturally occurred. On the other hand, mice that are deficient in acetylcholine receptors, mice that have been fed with NGF receptor blockers, and mice that have plexus-removed cells do not exhibit this phenomenon of accelerated gastric cancer due to nerve signals. Therefore, it can be considered that during the occurrence of gastric cancer, nervous tension plays a role through acetylcholine.
Based on the above results, the research team believes that the comprehensive application of NGF antibodies and NGF receptor blockers on the basis of existing anticancer agents will improve the therapeutic effect of gastric cancer.
The results of this study were published in the American scientific journal CANCER CELL.
Source: Ministry of Science and Technology
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