Chinese scientists discover genetic variants associated with gout in Han males

September 29, 2015 Source: Bio Valley

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Professor Li Changgui from the Affiliated Hospital of Qingdao University School of Medicine published a paper in the "Scientific Reports" that they identified a single nucleotide polymorphism in a gene associated with the risk of gout attacks in Chinese Han males. The rs10889677 mutation in the IL-23R gene may have led to the development of gout conditions in Han men.

Gout is an inflammatory arthritis in which monosodium urate crystals are precipitated in the joints due to elevated uric acid levels, resulting in recurrent acute pain. At the same time, gout belongs to an autoimmune disease. However, the incidence of gout varies in different geographical regions and different ethnic groups. Previous studies focusing on genetic variation associated with uric acid metabolism have failed to provide a comprehensive explanation for the causes of gout.

The genes for interleukins and interleukin receptors may be associated with autoimmune diseases due to their involvement in innate immunity, and thus may be considered to be related to the susceptibility to gout. The aim of this study was to understand whether there are genetic mutations in interleukins and interleukin receptors in Chinese Han males that can determine the susceptibility to gout. Professor Li Changgui of Qingdao University and his research team recruited 1,100 men with gout and 1227 ethnically matched controls.

The researchers found several genetic variants that may be associated with gout, such as interleukins, interleukin receptors, and signal transduction factors. Further analysis showed that the rs10889677 variation in the interleukin receptor gene IL-23R was significantly associated with the susceptibility of gout in Chinese Han males. The researchers indicated that further research is needed in other ethnic groups to confirm these findings. By understanding the gout-related gene mutations in the Han ethnic group, it can be used as one of the basis for the early diagnosis of the disease, and also provides a direction for the corresponding treatment strategy.

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