At present, the production of tablets in China is still widely used in wet granule tableting, but the application of powder direct compression technology in domestic and foreign pharmaceutical companies is gradually receiving attention.
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Tablets are a widely used dosage form of Zui, and their preparation can be divided into two types: particle tableting method and direct tableting method. The granule tableting method can be divided into two types according to the process of preparing granules: wet granule tableting method and dry granule tableting method; and direct tableting method is divided into powder direct compression method and crystallization directly due to different main drug properties. Tableting method. Direct tableting of the powder means that the powder of the drug is separately sieved and mixed with a suitable excipient, and then directly compressed into tablets without being subjected to granulation (wet granules or dry granules).
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Powder direct compression technology is an emerging research topic worthy of study. Once this technology matures, it can save a lot of process links, so it has received much attention. Today, in the pharmaceutical industry, domestic applications of wet granules are widely used. However, with the development of new excipients, the application of powder direct compression method has become more and more widespread. Â
In the traditional wet granulation, factors such as the amount of binder added, the drying time of the granules, the granulation time of the granules of the granules, etc., the number of machines required for production is large, the space is large, and some factors need to rely on experience judgment, which may result in Product quality is unstable, and there are large differences between batches. The direct compression technology ziu has the obvious advantage that it reduces the cost of equipment and operation: its production process is simple, no granulation, sieving, drying, sizing and intermediate sampling testing are required, which reduces the investment in the corresponding equipment factory and Inspection cost and labor intensity, saving time and energy, and not determining the quality of the product due to the experience of the workers, so that the quality of the final product is stable, the difference between batches is small, the operability is strong, the continuous production is guaranteed, especially suitable for GMP requirements. Production management.
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The drug for direct compression of the powder should have a certain thickness or crystal form; the drug powder should have good fluidity, compressibility and lubricity. However, most drugs do not have these characteristics, which need to be solved by improving the performance of the material and improving the performance of the tablet press.
Powder direct compression technology is worth looking forward to.
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