Release date: 2017-10-23
For the first time, British scientists have developed human bones in the laboratory and are expected to be used in orthopedics in the near future.
Researchers at the University of Glasgow, Strathclyde, Western Scotland and Galway University suspended volunteer-derived mesenchymal stem cells in collagen gels. Mesenchymal stem cells are produced by human bone marrow and can differentiate into cartilage, ligaments, tendons, fats and bones. Subsequently, the researchers used nano-reverse technology to generate about 1000 nano-level vibrations per second, turning the cells in the collagen gel into 3D bone cells. These bone cells can be implanted in patients in the future, repairing or replacing damaged bone parts, treating fractures, filling bone gaps after hip and knee replacement. In view of the use of the patient's own mesenchymal stem cells, rejection is less likely to occur, thereby filling a larger bone gap.
Bone is one of the main transplant tissues, mainly used for reconstruction, orthopedics and other operations. At present, doctors can only obtain limited living bones for transplantation from patients themselves, which not only increases the patient's surgical pain, but also is prone to infection; while others' bones are easily rejected.
The research report is published in the latest issue of the British journal Nature Biomedical Engineering. The researchers wrote in the report that the first human trial will be conducted in 2020.
Source: Xinhua News Agency
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