Researchers have developed biomedical 3D printing stents that control stem cell differentiation

3D bioprinting is often thought of as having the potential to subvert the medical world through regenerative implants, and may even lead to the emergence of artificial organs and tissues. A number of research institutions around the world are conducting research competitions on 3D printed cell structures. However, they all face a major obstacle: how can 3D print a stent and let the cells grow in the way the researchers want? Today, this obstacle is being solved by researchers at the Moroni Laboratory at Maastricht University in the Netherlands, and their pioneering design of several 3D printed stents demonstrates how progressive stem cells can differentiate into skeletal cells through progressive effects.

Obviously, this is a very important step towards 3D printed bone implants. It is understood that the Moroni laboratory, which has achieved this result, is one of the largest bio-manufacturing centers in Europe. The lab was founded two years ago and is part of the MERLN Regenerative Medicine Technology Institute at Maastricht University. In fact, the laboratory's origins can be traced back to 2009, and the research team was first established at Twente University. Since then, they have grown into a key component of the Brightlands ecosystem. Brightlands has been working with hospital clinical departments to create new biomedical 3D printing projects.

According to the researchers, their goal is to develop a complete database of 3D scaffolds that can control the "destiny" of cells - whether they become skin cells, bone cells or other types of cells. “The cells in the first generation are suspended in hydrogels or implanted in 3D porous matrices. These products demonstrate the potential of regenerative medicine treatment by reducing pain and restoring tissue continuity. But the function of these regenerative tissues Not always the same as the original," they explained. “This will cause degeneration after a few years of surgery, so surgery is needed again.”

The reasons here are manifold, but the most important factor is the need for a 3D environment for cell proliferation and homeostasis. Due to the dominant cell dominant deletion, the proliferating cells produce a different extracellular matrix that is inconsistent with the target tissue it should regenerate. "In addition, surgery with these products usually involves two steps, isolating and proliferating cells taken from tissue biopsies, and planting the cells on the stent before implantation. This usually requires patients to stay longer in the hospital. Time, which increases medical costs," they added.

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