[ China Pharmaceutical Network Technology News ] Microfluidic chip refers to the integration of basic operating units of biological, chemical or medical laboratories on a nanometer-scale microchip to achieve all the functions of the laboratory. Recently, researchers at the University of Oregon recently reported that the use of microfluidic chips to read parasitic worm electrophysiological signals can be used to screen potential anti-parasitic helminth compounds. This result brings hope to speed up research on new drugs for parasitic worms. .
The University of Oregon study was conducted primarily on ground-borne worms. Soil-borne worms include aphids, hookworms, whipworms, aphids, etc. These parasitic worms do not require an intermediate host, and their eggs or larvae can infect humans directly from the outside to the infected stage. Many people have been infected with more than one kind of soil-borne worms. They live and lay eggs in the human intestines, which may lead to diseases such as anemia and malnutrition, which cause serious damage to human health, especially children's development.
University of Oregon biologist Janis Wicks and colleagues have previously developed a microfluidic chip that can be used to study the central nervous system of tiny organisms. Their use of this microfluidic chip for C. elegans studies has shown that this nematode has an electrophysiological signal when it has a rhythmic contraction. Inspired by this, researchers believe that this microfluidic chip is expected to be used for anti-parasitic helminth drug research.
The researchers fed parasitic worms placed on microfluidic chips, causing their pharynx to contract rhythm. The microfluidic chip captures the electrophysiological signals between the worm's neurons and the muscles, thereby monitoring the pharyngeal movement of the worm. The researchers then injected compounds into the device that could damage the pharyngeal movements of the worms, observing which compounds actually destroyed the pharyngeal contractions of the worms and eventually starved them. On this microfluidic chip, researchers can screen for potentially anti-parasitic helminth compounds on eight living parasitic worms at a time.
Wicks said that there are some shortcomings in the treatment of soil-borne worms, such as the increasing resistance of parasitic helminths and the need for different treatments for different worms. She believes that microfluidic chips can be a powerful tool for speeding up the screening and development of new anti-parasitic worms.
The report was published in the new online publication International Journal of Parasitology: Drugs and Drug Resistance.
(Microfluidic chip is expected to accelerate the pace of research on new parasitic worms. Source: Baidu Pictures)
The University of Oregon study was conducted primarily on ground-borne worms. Soil-borne worms include aphids, hookworms, whipworms, aphids, etc. These parasitic worms do not require an intermediate host, and their eggs or larvae can infect humans directly from the outside to the infected stage. Many people have been infected with more than one kind of soil-borne worms. They live and lay eggs in the human intestines, which may lead to diseases such as anemia and malnutrition, which cause serious damage to human health, especially children's development.
University of Oregon biologist Janis Wicks and colleagues have previously developed a microfluidic chip that can be used to study the central nervous system of tiny organisms. Their use of this microfluidic chip for C. elegans studies has shown that this nematode has an electrophysiological signal when it has a rhythmic contraction. Inspired by this, researchers believe that this microfluidic chip is expected to be used for anti-parasitic helminth drug research.
The researchers fed parasitic worms placed on microfluidic chips, causing their pharynx to contract rhythm. The microfluidic chip captures the electrophysiological signals between the worm's neurons and the muscles, thereby monitoring the pharyngeal movement of the worm. The researchers then injected compounds into the device that could damage the pharyngeal movements of the worms, observing which compounds actually destroyed the pharyngeal contractions of the worms and eventually starved them. On this microfluidic chip, researchers can screen for potentially anti-parasitic helminth compounds on eight living parasitic worms at a time.
Wicks said that there are some shortcomings in the treatment of soil-borne worms, such as the increasing resistance of parasitic helminths and the need for different treatments for different worms. She believes that microfluidic chips can be a powerful tool for speeding up the screening and development of new anti-parasitic worms.
The report was published in the new online publication International Journal of Parasitology: Drugs and Drug Resistance.
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