Release date: 2015-01-08
Recently, in a research paper published in the international journal Analytica Chimica Acta , researchers from the University of Texas and other places have developed a new method that can help detect estrogen levels in a small number of samples, or A method of detecting potential improvements in cancer and other diseases.
We all know that estrogen plays an important role in the human body, and it is also directly related to tumor growth and the loss of neurons in the brain of Alzheimer's patients, but the detection of traces of females in blood and other body fluids. Hormones are very difficult, especially under limited conditions in the laboratory. In this study, researchers combined advanced mass spectrometry with chromatographic instruments to develop a new sensitive and effective method for detecting trace estrogens, which can detect less than 10 trillionth of a sample in a 100 microliter sample. Estrogen.
Researcher Professor Jose Barrera said that this new technology has pushed the minimum detection limit of estrogen to a new level, which is very important for us to conduct human disease and pharmaceutical research; mass spectrometry and chromatography can be used in complex mixtures. Separation, identification, and quantification of molecules involving liquid chromatography-electrospray ionization-tandem mass spectrometry, which relies on a critical step in charge derivatization, or the use of permanently charged reagents to selectively induce estrogen, and Estrogen is separated from lipids and proteins, and finally estrogen is detected.
Current methods for estrogen detection rely on antibodies, which use a protein detection system that is time consuming, less reliable, and requires more than 100 microliters of sample; the new method not only takes less sample but can also be in 25 minutes. The sample is tested inside. Finally, the researcher Beinhauer said that estrogen can play an important biological function, which not only plays an important role in the individual's sexual development and reproduction, but also can effectively regulate other functions of the body. Even the concentration of metabolically active estrogen. Very low, but it can show strong biological activity. The new estrogen detection technology developed in this paper will greatly help the pathogenesis of researchers' diseases.
Source: Bio Valley
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