Release date: 2013-06-28
Recently, researchers from Sweden and the United States successfully captured the process of transporting water molecules through the membrane by yeast aquaporin (inhibiting protons from passing through the cell membrane). The relevant research results were published in the international journal Science, and the researchers described it in the article. How to use ultra-high resolution microscopy to reveal the entire transport process of yeast aquaporin. In order for cells to function properly in the body, they must allow water molecules to enter the cell from outside the cell. This is also a way for cells to take up nutrients; of course, in this process, unwanted substances from cells can also be prevented from entering cells. How this whole process happens is a bit mysterious, because the aquaporin (channel) is very small, and the traditional method can only get a snapshot view. However, some researchers have previously developed a new technology that can be used to image how potassium ions are transported through potassium channels; the researchers used a similar approach to the passage of Pichia through aquaporin 1 The process of transportation is carried out. The researchers used an ultra-high resolution technique of only 0.88 angstroms to photograph the entire process and found that the process of yeast transport using aquaporin 1 is similar to the process of potassium transport; the researchers say that hydrogen bonding in this process Formation can inhibit protons from passing through the cell membrane with water molecules. It is important to note that the researchers also found two special structures, NPA-labeled sequences and selective filters formed by water molecules that prevent unwanted protons from entering the cell membrane. Promotes the passage of certain molecules through the microporous channels. The development of this new technology marks a new era of ultra-high-resolution recording of cell membrane transport, and provides ideas and hopes for future research into how water molecules carry unwanted substances into the interior of cells.
Source: Bio Valley
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